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Timothy D W Claridge Selected Research

Ketoglutaric Acids (Ketoglutaric Acid)

3/20182-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.
11/2017Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
9/2014Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.
3/2014Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
4/2011Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
10/2005Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.

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Timothy D W Claridge Research Topics

Disease

14Hypoxia (Hypoxemia)
03/2018 - 06/2002
7Neoplasms (Cancer)
01/2022 - 05/2011
3Multiple Sclerosis
01/2021 - 09/2015
1Inflammation (Inflammations)
10/2020
1Malaria
02/2017
1Liver Neoplasms (Liver Cancer)
10/2016
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
09/2015
1Spinal Muscular Atrophy (Progressive Muscular Atrophy)
04/2015
1HIV Infections (HIV Infection)
03/2015
1Chronic Progressive Multiple Sclerosis
10/2014

Drug/Important Bio-Agent (IBA)

9Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
03/2018 - 05/2011
6Ketoglutaric Acids (Ketoglutaric Acid)IBA
03/2018 - 10/2005
4Biomarkers (Surrogate Marker)IBA
01/2022 - 10/2014
4Proteins (Proteins, Gene)FDA Link
01/2021 - 06/2002
4Oxygen (Dioxygen)IBA
01/2016 - 06/2002
3EnzymesIBA
03/2018 - 03/2014
3Transcription Factors (Transcription Factor)IBA
01/2016 - 10/2005
3OxygenasesIBA
09/2015 - 05/2011
2MetalsIBA
04/2015 - 01/2013
2Mixed Function Oxygenases (Monooxygenases)IBA
01/2013 - 05/2011
1Inositol (Myoinositol)IBA
01/2021
1Oligoclonal BandsIBA
01/2021
1Glucose (Dextrose)FDA LinkGeneric
01/2021
1diphenyl (biphenyl)IBA
10/2020
1AntioxidantsIBA
10/2020
1BromidesIBA
10/2020
1Glutamine (L-Glutamine)FDA Link
10/2020
1Glutamic Acid (Glutamate)FDA Link
10/2020
1SYBR Green IIBA
02/2017
1phenolic acidIBA
02/2017
1OligosaccharidesIBA
02/2017
1Carbon DioxideIBA
10/2016
1Pyruvic Acid (Pyruvate)IBA
10/2016
1Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA
10/2016
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
10/2016
1DNA (Deoxyribonucleic Acid)IBA
10/2016
1Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
10/2016
1Exonucleases (3' 5' Exonuclease)IBA
10/2016
1N-(2-mercaptoethyl)-1,3-diaminopropaneIBA
10/2016
1Oxidoreductases (Dehydrogenase)IBA
10/2016
1Amifostine (Ethyol)FDA LinkGeneric
10/2016
1Protein Isoforms (Isoforms)IBA
01/2016
1fluorophosphate (sodium monofluorophosphate)FDA Link
04/2015
1NucleotidesIBA
04/2015
1TriazolesIBA
01/2015
1CollagenIBA
09/2014
1Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
03/2014
1Histone DemethylasesIBA
01/2013
1Lysine (L-Lysine)FDA Link
05/2011
1Histones (Histone)IBA
05/2011
1DioxygenasesIBA
04/2011
1AsparagineIBA
03/2011
1Aspartic Acid (Aspartate)FDA Link
03/2011
1AnkyrinsIBA
03/2011
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
06/2002

Therapy/Procedure

3Therapeutics
10/2020 - 03/2015
1Traditional Medicine (Folk Remedies)
02/2017